Antibodies specific for N-terminal truncated and pyroglutamate modified amyloid-beta peptides

US8058405B2 · kind B2 · utility

Assignee

• PROBIODRUG AG · DE

Inventors

• Hans-Ulrich Demuth · Halle (Saale), DE
• Stephan Schilling · Halle (Saale), DE
• Martin Kleinschmidt · Halle (Saale), DE
• Kathrin Gans · Halle (Saale), DE
• Anita Reisenauer-Schaupp · Bad Wurzach, DE
• Jens-Ulrich Rahfeld · Lieskau, DE
• Sonja Kampfer · Germering, DE

Key dates

• Filing date: Jul 10, 2009
• Grant date: Nov 15, 2011
• Expiry date: Nov 2, 2029

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2800/387
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention pertains to novel diagnostic assays for the diagnosis of amyloidosis, in particular Alzheimer's disease, and related aspects. In particular, monoclonal antibodies and an antibody assay are provided.