Patent · US Active

Biosynthetic pathway and genes required for tropodithietic acid biosynthesis in silicibacter TM1040

US8058417B2 · kind B2 · utility

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Inventors

Robert Belas · Catonsville, US
Haifeng Geng · Beijing, CN
Ryan Joseph POWELL · Baltimore, US

Key dates

Filing date	May 26, 2009
Grant date	Nov 15, 2011
Priority date	—
Expiry date	May 26, 2029

Classification

Technology area (CPC Y)Emerging Cross-Sectional Technologies
CPC primaryY02A50/30
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Production and use of a sulfur-containing compound, tropodithietic acid (TDA), from the roseobacter Silicibacter sp. TM1040 is described. Specifically, a biosynthetic and regulatory pathway for TDA biosynthesis in roseobacters is described. The TDA produced from roseobacters, specifically Silicibacter sp. TM1040, is shown to have antibacterial activity, in particular against Vibrio anguillarium, Vibrio cholerae, Vibrio coralliilyticus, Vibrio shiloi, Halomonas spp., Mycobacterium marinum, Mycobacterium tuberculosis, Pseudomonas elongate, Spongiobacter nikelotolerans, and Staphylococcus aureus (MRSA).

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.