Synthesis of 5-azacytidine
US8058424B2 · kind B2 · utility
19Cited by
13References
31Claims
0Family size
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Key dates
| Filing date | Dec 20, 2010 |
| Grant date | Nov 15, 2011 |
| Priority date | — |
| Expiry date | Dec 20, 2030 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07H19/12
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention provides a method for the preparation of 5-azacytidine, wherein 5-azacytidine is represented by the structure:The method involves the silylation of 5-azacytosine, followed by the coupling of silylated 5-azacytosine to a protected β-D-ribofuranose derivative. The coupling reaction is catalyzed by trimethylsilyl trifluoromethanesulfonate (TMS-Triflate).
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.