HCI polymorphs of 3-((2-(dimethylamino)methyl(cyclohex-1-yl)) phenol

US8058476B2 · kind B2 · utility

Assignee

• Gruenenthal GmbH · DE

Inventors

• Michael Gruss · Aachen, DE
• Andreas Fischer · Castro Valley, US
• Markus Kegel · Aachen, DE
• Wolfgang Hell · Aachen, DE
• Markus Von Raumer · Allschwil, CH
• Joerg Berghausen · Vilsbiburg, DE
• Susan Margaret Paul · Zürich, CH

Key dates

• Filing date: Jan 18, 2008
• Grant date: Nov 15, 2011
• Expiry date: Feb 13, 2028

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2601/14
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A crystalline salt of 3-[2-(dimethylamino)methyl(cyclohex-1-yl)]phenol and hydrogen chloride, preferably in a 1:1 composition, including various crystalline forms of this salt, processes for preparing the various crystalline forms of this salt, pharmaceutical compositions containing the various crystalline forms of this salt, and the use of this salt as a pharmacologically active agent in a pharmaceutical composition to treat or inhibit pain or other disorders or disease states.