Increasing lifespan by modulation of WWP-1 and UBC-18
US8058502B2 · kind B2 · utility
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Key dates
| Filing date | Aug 15, 2008 |
| Grant date | Nov 15, 2011 |
| Priority date | — |
| Expiry date | Jan 24, 2029 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2500/00
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Ubiquitin ligase wwp-1 and ubiquitin conjugating enzyme ubc-18 are identified in nematodes as mediators of dietary restriction induced longevity and therefore as targets for modulation of lifespan in animals. Methods of screening for compounds that modulate longevity by assaying wwp-1 ubiquitination pathway parameters are provided, as are related systems. In addition, methods of using wwp-1 and/or ubc-18 to modulate longevity or delay onset of age-related diseases are described.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.