Nucleic acids encoding antibodies to IL-6, and recombinant production of anti-IL-6 antibodies

US8062864B2 · kind B2 · utility

Assignee

• ALDERBIO HOLDINGS LLC · US

Inventors

• Leon F. Garcia-Martinez · Woodinville, US
• Anne Elisabeth Carvalho Jensen · San Francisco, US
• Katie Olson · Kenmore, US
• Ben Dutzar · Seattle, US
• Ethan W. Ojala · Snohomish, US
• Brian R. Kovacevich · Snohomish, US
• John Latham · Seattle, US
• Jeffrey T. L. Smith · Dublin, IE

Key dates

• Filing date: Feb 5, 2009
• Grant date: Nov 22, 2011
• Expiry date: Jul 7, 2029

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2317/92
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention is directed to antibodies and fragments thereof and humanized versions thereof having binding specificity for IL-6. Another embodiment of this invention relates to the antibodies described herein, and binding fragments thereof, comprising the sequences of the VH, VL and CDR polypeptides described herein, and the polynucleotides encoding them. The invention also contemplates conjugates of anti-IL-6 antibodies and binding fragments thereof conjugated to one or more functional or detectable moieties. The invention also contemplates methods of making said anti-IL-6 antibodies and binding fragments thereof. Embodiments of the invention also pertain to the use of anti-IL-6 antibodies, and binding fragments thereof, for the diagnosis, assessment and treatment of diseases and disorders associated with IL-6. These antibodies may bind at least one of soluble IL-6, cell surface expressed IL-6, IL-6/IL-6R and/or prevent the association of IL-6 and IL-6R, the association of IL-6/IL-6R and gp130 and or the formation of IL-6/IL-6R/gp130 multimers and thereby inhibit a biological effect associated with any of the foregoing.