Method for activating prethrombin-1
US8062876B2 · kind B2 · utility
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19Claims
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Key dates
| Filing date | Dec 21, 2006 |
| Grant date | Nov 22, 2011 |
| Priority date | — |
| Expiry date | Feb 21, 2029 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Y304/21005
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Methods for converting prethrombin-1 to thrombin are disclosed. An aqueous solution of prethrombin-1 is applied to oscutarin-C immobilized on a solid support so as to provide from 500 mg to 4000 mg of prethrombin-1 per mL of the solid support and a contact time between the prethrombin-1 and the oscutarin-C of from 1.8 to 3.5 minutes. The resulting active thrombin may be captured on an ion exchange chromatography medium or an affinity chromatography medium.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.