Trans-3-aza-bicyclo[3.1.0]hexane derivatives

US8063099B2 · kind B2 · utility

Assignee

• Actelion Pharmaceuticals Ltd. · CH

Inventors

• Hamed Aissaoui · Allschwil, CH
• Christoph Boss · Allschwil, CH
• Markus Gude · Allschwil, CH
• Ralf Koberstein · Bad Kötzting, DE
• David Lehman · Bern, CH
• Thierry Sifferlen · Allschwil, CH
• Daniel TRACHSEL · Bern, CH

Key dates

• Filing date: Jul 25, 2008
• Grant date: Nov 22, 2011
• Expiry date: Jul 25, 2028

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D513/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The invention relates to novel trans-3-aza-bicyclo[3.1.0]hexane derivatives of formula (I), wherein A, B, n and R1 are as described in the description, and to the use of such compounds, or of pharmaceutically acceptable salts of such compounds, as medicaments, especially as orexin receptor antagonists.