Phosphonyl ester conjugates as prodrugs

US8063209B2 · kind B2 · utility

Assignees

• TSRL, Inc. · US
• NATIONAL INSTITUTES OF HEALTH (NIH) · US
• The United States of America as represented by the Department of Health and Human Services (DHHS) · US
• NIH Division of Extramural Inventions and Technology Resources (DEITR) · US

Inventors

• John Hilfinger · Ann Arbor, US
• Charles E. McKenna · Santa Monica, US
• Boris A. Kashemirov · Los Angeles, US
• Chi Pham · Lawndale, US
• Kanokkarn Saejueng · Los Angeles, US
• Larryn W. Peterson · Mountain View, US

Key dates

• Filing date: Mar 16, 2009
• Grant date: Nov 22, 2011
• Expiry date: Jun 28, 2029

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Cidofovir or foscarnet based compounds having an amino acid or dipeptide esters are provided as prodrugs.