Azacycloalkane derivatives as inhibitors of stearoyl-coenzyme a delta-9 desaturase
US8063224B2 · kind B2 · utility
7Cited by
1References
13Claims
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Key dates
| Filing date | Nov 30, 2007 |
| Grant date | Nov 22, 2011 |
| Priority date | — |
| Expiry date | Sep 21, 2030 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D417/14
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Azacycloalkane derivatives of structural formula I are selective inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD1) relative to other known stearoyl-coenzyme A desaturases. The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease, such as atherosclerosis; obesity; diabetes; neurological disease; metabolic syndrome; insulin resistance; and liver steatosis.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.