Attenuated poliovirus

US8066983B2 · kind B2 · utility

Assignee

• The Research Foundation of the State University of New York · US

Inventors

• Eckard Wimmer · Port Jefferson, US
• Jeronimo Cello · Port Jefferson, US
• Aniko Paul · Setauket, US
• Hidemi Toyoda · Port Jefferson, US
• Jiang Yin · Port Jefferson, US

Key dates

• Filing date: Mar 16, 2009
• Grant date: Nov 29, 2011
• Expiry date: Mar 16, 2029

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2840/203
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A novel and stable attenuated poliovirus, which replicates in neuroblastoma cells, is produced by engineering an indigenous replication element (cre), into the 5′ non-translated genomic region and inactivating the native cre element located in the coding region of 2C (mono-crePV). The stably attenuated poliovirus replicates in a neuroblastoma model (Neuro-2aCD155 tumors) expressing CD155, the poliovirus receptor, and is effective for oncolytic treatment and cure of solid tumors, such as neuroblastoma.