Compositions and systems for forming crosslinked biomaterials and associated methods of preparation and use

US8067031B2 · kind B2 · utility

Assignee

• Angiodevice International GmbH · CH

Inventors

• George Y. Daniloff · Los Altos, US
• Louis C. Sehl · Redwood City, US
• Olof Mikael Trollsas · San Jose, US
• Jacqueline A. Schroeder · Redwood City, US
• David Gravett · Palo Alto, US
• Philip M. Toleikis · Vancouver, CA

Key dates

• Filing date: Apr 28, 2005
• Grant date: Nov 29, 2011
• Expiry date: Jul 24, 2027

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Crosslinkable compositions are provided that readily crosslink in situ to provide crosslinked biomaterials. The composition contains at least two biocompatible, non-immunogenic components having reactive groups thereon, with the functional groups selected so as to enable inter-reaction between the components, i.e., crosslinking. In one embodiment, a first component has nucleophilic groups and a second component has electrophilic groups. Additional components may have nucleophilic or electrophilic groups. Methods for preparing and using the compositions are also provided as are kits for delivery of the compositions. Exemplary uses for the crosslinked compositions include tissue augmentation, biologically active agent delivery, bioadhesion, and prevention of adhesions following surgery or injury.