Method for preparing submicron particles of antineoplastic agents
US8067032B2 · kind B2 · utility
2Cited by
147References
31Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Nov 7, 2003 |
| Grant date | Nov 29, 2011 |
| Priority date | — |
| Expiry date | Feb 4, 2025 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K9/1688
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention is concerned with the formation of submicron particles of an antineoplastic agent, particularly paclitaxel, by precipitating the antineoplastic agent in an aqueous medium to form a pre-suspension followed by homogenization. Surfactants with phospholipids conjugated with a water soluble or hydrophilic polymer such as PEG are used as coating for the particles. The particles produced generally have an average particle size of less than about 1000 nm and are not rapidly soluble.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.