Insulin derivatives
US8067362B2 · kind B2 · utility
17Cited by
3References
6Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Feb 1, 2006 |
| Grant date | Nov 29, 2011 |
| Priority date | — |
| Expiry date | Feb 1, 2026 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K14/62
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to insulin derivatives having a side chain attached either to the -amino group of the N-terminal amino acid residue of the B chain or to the amino group of a Lys residue present in the B chain of the parent insulin via an amide bond which side chain comprises at least one aromatic group; at least one free carboxylic acid group or a group which is negatively charged at neutral pH, a fatty acid moiety with 4 to 22 carbon atoms in the carbon chain; and possible linkers which link the individual components in the side chain together via amide bonds.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.