Silencing of TGFβ type II receptor expression by siRNA

US8067389B2 · kind B2 · utility

Assignee

• The Broad of Trustees of the University of Illinois · US

Inventors

• Nalin M. Kumar · Wilmette, US
• Beatrice Yue · Deerfield, US
• Shahid Siddiqui · Wilmette, US
• Asrar Malik · Chicago, US
• Jose S. Pulido · Rochester, US

Key dates

• Filing date: Jul 20, 2009
• Grant date: Nov 29, 2011
• Expiry date: Jul 20, 2029

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2310/14
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present application is directed to siRNA-based silencing of the type II receptor of TGFβ. siRNAs that target this receptor abrogate the receptor protein and transcript, TGFβ-mediated processes such as fibronectin assembly and cell migration also are inhibited and the molecules of the invention are efficacious in reducing the inflammatory response and matrix deposition. These findings show that siRNAs can be successfully delivered both in vitro and in vivo to regulate the TGFβ type II receptor level and modulate wound response. Methods and compositions exploiting the findings of the present invention have a wide-ranging application, extending from treatment of disorders of the eye to other organs and tissues throughout the body.