Macrocyclic compounds useful as inhibitors of kinases and HSP90
US8067412B2 · kind B2 · utility
9Cited by
50References
36Claims
0Family size
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Key dates
| Filing date | Aug 10, 2007 |
| Grant date | Nov 29, 2011 |
| Priority date | — |
| Expiry date | Sep 14, 2029 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D493/04
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Disclosed are macrocyclic compounds of formulae I-V, which are analogs of the pochonin resorcylic acid lactones, and processes for the preparation of the compounds. The compounds disclosed are useful as inhibitors of kinases and Heat Shock Protein 90 (HSP 90). Also disclosed are pharmaceutical compositions comprising an effective kinase-inhibiting amount or an effective HSP90-inhibiting amount of the compounds and methods for the treatment of disorders that are mediated by kinases and HSP90.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.