Nitrogen-containing heterocyclic compounds, their preparation and their use as antibacterial drugs

US8067435B2 · kind B2 · utility

Assignee

• ASTRAZENECA AB · SE

Inventors

• Maxime Lampilas · Limoges, FR
• David Alun Rowlands
• Benoit Ledoussal · Meaux, FR
• Marie-Edith Gourdel · Romainville, FR
• Emilie Renaud · Romainville, FR
• Camille Pierres · Romainville, FR
• Adel Kebsi · Romainville, FR

Key dates

• Filing date: Aug 5, 2009
• Grant date: Nov 29, 2011
• Expiry date: Jan 14, 2030

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P31/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The invention relates to nitrogen-containing heterocyclic compounds of general formula (I)wherein:R1 represents a (CH2)n—NH2 radical, n being equal to 1 or 2;R2 represents a hydrogen atom;R3 and R4 form together a nitrogen-containing heterocycle with aromaticity with 5 apices containing 1, 2 or 3 nitrogen atoms, substituted on this nitrogen atom or one of these nitrogen atoms with a (CH2)m—(C(O))p—R5 group, m being equal to 0, 1, 2 or 3, p being equal to 0 or 1 and R5 representing a hydroxy group, in which case p is equal to 1, or an amino, (C1-C6)alkyl or di-(C1-C6)alkyl amino, a nitrogen-containing heterocycle with aromaticity with 5 or 6 apices containing 1 or 2 nitrogen atoms and if necessary, an oxygen or sulfur atom;