5-phenoxyalkoxypsoralens and methods for selective inhibition of the voltage gated Kv1.3 potassium channel

US8067460B2 · kind B2 · utility

Assignee

• The Regents of the University of California · US

Inventors

• Heike Wulff · Davis, US
• Ananthakrishnan Sankaranarayanan · Davis, US
• Wolfram Haensel · Kronshagen, DE
• Alexander Schmitz · Andernach, DE
• Kristina Schmidt-Lassen · Kiel, DE

Key dates

• Filing date: Jul 6, 2009
• Grant date: Nov 29, 2011
• Expiry date: Nov 15, 2029

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P37/06
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compositions of matter comprising 5-phenoxyalkoxypsoralen compounds and their method of synthesis and use. The compounds are useable to treat diseases or disorders in human or animal subjects, including autoimmune diseases. The compounds inhibit potassium channels, including the Kv1.3 channel and at least some of the therapeutic effects of such compounds may be due at least in part to potassium channel inhibition. In some embodiments, the compounds are more selective for certain potassium channels (e.g., Kv1.3 channels) than other potassium channels (e.g., Kv1.5 channels).