Antibodies against T cell immunoglobulin domain and mucin domain 1 (TIM-1) antigen and uses thereof

US8067544B2 · kind B2 · utility

Assignee

• Curagen Corporation · US

Inventors

• Gregory Landes · San Bruno, US
• Francine Zhifen Chen · San Francisco, US
• Binyam Bezabeh · Gaithersburg, US
• Ian Foltz · Burnaby, CA
• Kam Fai Tse · Radnor, US
• Michael Jeffers · Branford, US
• Mehdi Mesri · North Potomac, US
• Gary Starling · Clinton, US
• Peter Mezes · Old Lyme, US
• Nikolia Khramtsov · Branford, US

Key dates

• Filing date: Mar 19, 2004
• Grant date: Nov 29, 2011
• Expiry date: Oct 31, 2027

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2333/70503
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention described herein is related to antibodies directed to the antigen TIM-1 and uses of such antibodies. In particular, there are provided fully human monoclonal antibodies directed to the antigen TIM-1. Isolated polynucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions (FR's) and/or complementarity determining regions (CDR's), specifically from FR1 through FR4 or CDR1 through CDR3, are provided. Hybridomas or other cell lines expressing such immunoglobulin molecules and monoclonal antibodies are also provided.