Processes for the production of (+)- “Nal” morphinan compounds

US8067596B2 · kind B2 · utility

Assignee

• MALLINCKRODT LLC · US

Inventors

• Peter X. Wang · Chesterfield, US
• Tao Jiang · San Diego, US
• Gary L. Cantrell · Glen Carbon, US
• David W. Berberich · Saint Peters, US
• Bobby N. Trawick · Florissant, US
• Subo Liao · Ballwin, US

Key dates

• Filing date: Dec 17, 2008
• Grant date: Nov 29, 2011
• Expiry date: Mar 31, 2030

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P25/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The invention generally provides processes and intermediate compounds useful for the production of (+) nal morphinan compounds. In particular, the process encompasses synthetic routes for the production of (+) nal morphinan compounds or derivatives of (+) nal morphinan compounds from (+)-morphinan substrates such as (+)-hydrocodone, (+)-norhydrocodone or derivatives of either compound.