Method of improving signal-to-noise for quantitation by mass spectrometry
US8067728B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Feb 22, 2008 |
| Grant date | Nov 29, 2011 |
| Priority date | — |
| Expiry date | Feb 20, 2030 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N30/7233
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Selectivity of a measurement from a mass spectrometer is improved by selecting an extracted ion current window for the measurement after data acquisition. A plurality of mass spectra are acquired over a period of time. A first extracted ion current window is selected and from the plurality of mass spectra a first intensity as a function of time is calculated for an ion using the first extracted ion current window. A second extracted ion current window is selected and from the plurality of mass spectra a second intensity as a function of time is calculated for the ion using the second extracted ion current window. A first signal-to-noise ratio of the first intensity is compared with a second signal-to-noise ratio of the second intensity. If the second signal-to-noise ratio is greater than the first signal-to-noise ratio, the second intensity as a function of time is used for the measurement.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.