Method and device for selectively detecting ferromagnetic or superparamagnetic particles

US8071027B2 · kind B2 · utility

Assignee

• Forschungszentrum Jülich GmbH · DE

Inventors

• Peter Miethe · Schleberoda, DE
• Hans-Joachim Krause · Ludwigshafen, DE
• Yi Zhang · Lich, DE
• Norbert Wolters · Gescher, DE
• Dmitry Plaksin · Baesweiler, DE

Key dates

• Filing date: Jan 30, 2004
• Grant date: Dec 6, 2011
• Expiry date: May 26, 2027

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N27/745
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

The invention relates to a method for selectively detecting and/or quantifying superparamagnetic and/or ferromagnetic particles on analytes. The method is characterized in that a frequency component of magnetic fields (15, 18), which is generated due to the non-linearity of the magnetization characteristic curve of the particles, is measured at a mixing frequency. A device for selectively detecting and/or quantifying superparamagnetic and/or ferromagnetic particles on analytes comprises: a container (12) that contains particles, which are to be detected and/or quantified, on analytes; at least one oscillator (13, 16; 25) for generating frequencies of alternating magnetic fields (15, 18); at least one field generator (14, 17) for subjecting the analytes to alternating magnetic fields (15, 18); a magnetic field sensor (20) for measuring a response magnetic field (19) of the particles, and; at least one phase-sensitive detector (21, 23). These elements are configured in such a manner as to enable a frequency component of the magnetic fields (15, 18), which is generated due to the non-linearity of the magnetization characteristic curve of the particles, to be measured at a mixing frequ…