Nucleic acids encoding modified human immunodeficiency virus type 1 (HIV-1) group M consensus envelope glycoproteins

US8071107B2 · kind B2 · utility

Assignees

• Duke University · US
• The Regents of the University of California · US
• The University of Alabama at Birmingham Research Foundation · US

Inventors

• Barton F. Haynes · Durham, US
• Feng Gao · Hoover, US
• Bette T. Korber · Los Alamos, US
• Beatrice H. Hahn · Birmingham, US
• George M. Shaw · Birmingham, US
• Denise Kothe · Birmingham, US
• Ying Li · Basel, CH
• Julie Decker · Birmingham, US
• Hua-Xin Liao · Durham, US

Key dates

• Filing date: Sep 17, 2004
• Grant date: Dec 6, 2011
• Expiry date: Jan 5, 2027

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2740/16322
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates, in general, to an immunogen and, in particular, to an immunogen for inducing antibodies that neutralizes a wide spectrum of HIV primary isolates and/or to an immunogen that induces a T cell immune response. The invention also relates to a method of inducing anti-HIV antibodies, and/or to a method of inducing a T cell immune response, using such an immunogen. The invention further relates to nucleic acid sequences encoding the present immunogens.