Use of specific T2R taste receptors to identify compounds that block bitter taste

US8071320B2 · kind B2 · utility

Assignee

• SENOMYX, INC. · US

Inventors

• Alexey Pronin · San Diego, US
• Judy Connor · Vista, US
• Huixian Tang · San Diego, US
• Walter Keung · Encinitas, US
• Guy Servant · San Diego, US
• Jon Elliot Adler · San Diego, US
• Shawn O'Connell · Encinitas, US
• Paul Brust · San Diego, US

Key dates

• Filing date: Aug 11, 2010
• Grant date: Dec 6, 2011
• Expiry date: Aug 11, 2030

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2500/10
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

Assays for identifying compounds that modulate, preferably inhibit bitter taste associated with the activation of hT2R4, hT2R44 and/or hT2R61 are provided. The compounds identified according to these assays should modulate, e.g., inhibit bitter taste associated with bitter tasting compounds including quinine, 6-nitrosaccharin, saccharin and/or denatonium. These compounds are useful additives for foods, beverages or medicinal preparations having a bitter taste.