Method of increasing muscle mass by administering a myostatin binding agent
US8071538B2 · kind B2 · utility
14Cited by
7References
4Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Aug 23, 2010 |
| Grant date | Dec 6, 2011 |
| Priority date | — |
| Expiry date | Aug 23, 2030 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2333/475
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides binding agents comprising peptides capable of binding myostatin and inhibiting its activity. In one embodiment the binding agent comprises at least one myostatin-binding peptide attached directly or indirectly to at least one vehicle such as a polymer or an Fc domain. The binding agents of the present invention produced increased lean muscle mass when administered to animals and decreased fat to muscle ratios. Therapeutic compositions containing the binding agents of the present invention are useful for treating muscle-wasting disorders and metabolic disorders including diabetes and obesity.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.