Regulation of angiogenesis with zinc finger proteins

US8071564B2 · kind B2 · utility

Assignee

• Sangamo Biosciences, Inc. · US

Inventors

• Edward J. Rebar · Richmond, US
• Andrew Jamieson · San Francisco, US
• Qiang Liu · Saskatoon, CA
• Pei-Qi Liu · Richmond, US
• Alan Wolffe · Orinda, US
• Stephen P. Eisenberg · Boulder, US
• Eric Jarvis · Boulder, US

Key dates

• Filing date: Sep 3, 2009
• Grant date: Dec 6, 2011
• Expiry date: Sep 3, 2029

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2830/008
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Provided herein are a variety of methods and compositions for regulating angiogenesis, such methods and compositions being useful in a variety of applications where modulation of vascular formation is useful, including, but not limited to, treatments for ischemia and wound healing. Certain of the methods and compositions accomplish this by using various zinc finger proteins that bind to particular target sites in one or more VEGF genes. Nucleic acids encoding the zinc finger proteins are also disclosed. Methods for modulating the expression of one or more VEGF genes with the zinc finger proteins and nucleic acids are also disclosed. Such methods can also be utilized in a variety of therapeutic applications that involve the regulation of endothelial cell growth. Pharmaceutical compositions including the zinc finger proteins or nucleic acids encoding them are also provided.