2-oxo-3-benzylbenzoxazol-2-one derivatives and related compounds as Met kinase inhibitors for the treatment of tumours

US8071593B2 · kind B2 · utility

Assignee

• Merck Patent GmbH · DE

Inventors

• Oliver Schadt · Rodenbach, DE
• Dieter Dorsch · Ober-Ramstadt, DE
• Frank Stieber · Heidelberg, DE
• Andree Blaukat · Heilbad Heiligenstadt, DE

Key dates

• Filing date: May 8, 2008
• Grant date: Dec 6, 2011
• Expiry date: May 8, 2028

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D498/06
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Described are compounds which inhibit, regulate and/or modulate kinase signal transduction, for example of Met kinase. The compounds are of the formulae A1 to A148 and B1 described herein, including 2-oxobenzoxazol-3-ylmethyl]phenyl}carbamate and 2-oxooxazolo[4,5-b]pyridin-3-ylmethyl)phenyl]carbamate compounds, and pharmaceutically usable salts, tautomers and stereoisomers thereof, including mixtures thereof in all ratios. Also described are compositions containing these compounds. Also described are methods for the treatment of diseases in which the inhibition, regulation and/or modulation of kinase signal transduction plays a role by administering these compounds.