TRP/HIS exchange and kynurenin induced TRP transport
US8071744B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Apr 28, 2011 |
| Grant date | Dec 6, 2011 |
| Priority date | — |
| Expiry date | Apr 28, 2031 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2800/24
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The present invention provides methods for detecting changes in tryptophan concentrations in a cell and methods for identifying agents that modulate cellular tryptophan concentrations. In particular, the present invention provides methods for detecting cellular exchange between tryptophan and kynurenine, and methods for identifying agents that modulate this exchange. The present invention also provides methods for treating a disease associated with immunosuppression in a subject in need thereof. In particular, the present invention is directed toward a method of treating a disease associated with immunosuppression comprising contacting the disease with an agent that modulates cellular Trp/kynurenine exchange. Furthermore, the present invention provides methods for identifying an agent that modulates an immunosuppression.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.