Diagnosis and treatment of cancer related to human dormancy
US8075902B2 · kind B2 · utility
Inventor
Key dates
| Filing date | Jan 2, 2008 |
| Grant date | Dec 13, 2011 |
| Priority date | — |
| Expiry date | Jun 16, 2029 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K31/727
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
New devices and methods for diagnosis and compositions and methods for treatment of cancers use combinations of antimicrobial agents and agents that can reverse dormancy and hibernation pathways. We unexpectedly found that surprisingly low doses of anti-hibernation compounds can substantially inhibit cancer cell growth in vitro and can successfully treat cancers, including metastatic cancer. We also unexpectedly found that antimicrobial agents and anti-HDS compounds together can increase the degree of inhibition of cancer cell growth in a synergistic fashion. We conclude that combination therapy with antimicrobial agents and anti-HDS compounds can be effective in treating human patients with cancer.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.