Methods for fabrication, uses and compositions of small spherical particles prepared by controlled phase separation
US8075919B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Jul 19, 2004 |
| Grant date | Dec 13, 2011 |
| Priority date | — |
| Expiry date | Oct 24, 2026 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K9/5026
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention is related to a method for preparing small spherical particles of an active agent by providing a solution in a single liquid phase. The single liquid phase comprises an active agent, a phase separation enhancing agent, and a first solvent. A phase change is induced at a controlled rate in the solution to cause a liquid-solid phase separation of the active agent and to form a solid phase and a liquid phase. The solid phase comprises solid small spherical particles of the active agent. The liquid phase comprises the phase separation enhancing agent and the solvent. The small spherical particles are substantially spherical and having a size from about 0.01 μm to about 200 μm.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.