Patent · US Active

Gene encoding a multidrug-resistance human P-glycoprotein homologue on chromosome 7P15-21 and uses thereof

US8076091B2 · kind B2 · utility

14Cited by

7References

5Claims

0Family size

Assignee

The Brigham and Women's Hospital, Inc. · US

Inventors

Markus Frank · Baden-Baden, DE
Mohamed H. Sayegh · Dedham, US

Key dates

Filing date	Nov 19, 2008
Grant date	Dec 13, 2011
Priority date	—
Expiry date	Nov 19, 2028

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07K2317/34
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The invention relates to an MDR family P-glycoprotein located on human chromosome 7p15-21, polynucleotide sequences encoding this P-glycoprotein and fragments thereof. This gene is utilized in methods for assessing cancer cell susceptibility to therapies directed against multidrug resistance, and for the design of diagnostic and therapeutic methods relating to cancer multidrug resistance. The invention also relates to methods for determining whether a test compound may inhibit multidrug resistance.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.