Patent · US Active

Phosphorylation of histone H3 at threonine 11—a novel epigenetic mark for transcriptional regulation

US8076094B2 · kind B2 · utility

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1Claims

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Assignee

UNIVERSITAETSKLINIKUM FREIBURG · DE

Inventors

Roland Schuele · Kenzingen, DE
Eric Metzger · Neuf-Brisach, FR

Key dates

Filing date	May 27, 2008
Grant date	Dec 13, 2011
Priority date	—
Expiry date	May 27, 2028

Classification

Technology area (CPC G)Physics
CPC primaryG01N2500/00
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The present invention relates to a process for controlling at least one androgen receptor- (AR-) regulated mechanism in mammalian cells under histone-phosphorylating conditions, said process comprising allowing at least one inhibitor with specificity for at least one protein kinase C-related kinase (PRK) to act on said at least one PRK1 thereby modulating, preferably down-regulating, the activity of said at least one PRK and optionally blocking said at least one androgen receptor-regulated mechanism in said mammalian cells.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.