Patent · US Active

Plasmid maintenance system for antigen delivery

US8076130B2 · kind B2 · utility

1Cited by

19References

23Claims

0Family size

Assignee

UNIVERSITY OF MARYLAND, BALTIMORE · US

Inventors

James E. Galen · Owings Mills, US
Christofer Vindurampulle · Melbourne, AU

Key dates

Filing date	Oct 4, 2006
Grant date	Dec 13, 2011
Priority date	—
Expiry date	Jan 10, 2030

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12N15/74
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

The present invention relates generally to a Plasmid Maintenance System for the stabilization of expression plasmids encoding foreign antigens, and methods for making and using the Plasmid Maintenance System. The invention optimizes the maintenance of expression plasmids at two independent levels by: (1) removing sole dependence on balanced lethal maintenance functions; and (2) incorporating at least one plasmid partition function to prevent random segregation of expression plasmids, thereby enhancing their inheritance and stability. The Plasmid Maintenance System may be employed within a plasmid which has been recombinantly engineered to express a variety of expression products.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.