Patent · US Active

Biological pacemakers including mutated hyperpolarization-activated cyclic nucleotide-gated (HCN) channels

US8076305B2 · kind B2 · utility

2Cited by

15References

40Claims

0Family size

Assignee

Medtronic, Inc. · US

Inventors

Daniel Sigg · Saint Paul, US
Vinod Sharma · Bengaluru, IN
Yong-Fu Xiao · Blaine, US

Key dates

Filing date	Nov 30, 2006
Grant date	Dec 13, 2011
Priority date	—
Expiry date	Aug 25, 2030

Classification

Technology area (CPC A)Human Necessities
CPC primaryA61K38/00
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

A composition for implantation into cardiac tissue includes a biological pacemaker that, when implanted, expresses an effective amount of a mutated hyperpolarization-activated and cyclic nucleotide-gated (HCN) isoform to modify Ih when compared with wild-type HCN. Methods for implementing each of the biologocal pacemakers include implanting each of biologocal pacemakers into cardiac tissue.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.