Di(hetero)arylcyclohexane derivatives, their preparation, their use and pharmaceutical compositions comprising them

US8076324B2 · kind B2 · utility

Assignee

• Sanofi-Aventis · FR

Inventors

• Thomas Bohme · Adelsheim, DE
• Uwe Gerlach · Hattersheim, DE
• Dirk Gretzke · Frankfurt am Main, DE
• Heinz-Werner Kleemann · Bischofsheim, DE
• Stefania PFEIFFER-MAREK · Frankfurt, DE
• Henning Vollert · Bad Segeberg, DE
• Jean-Michel Altenburger · Le Puy-en-Velay, FR
• Sergio Mallart · Paris, FR

Key dates

• Filing date: Dec 3, 2009
• Grant date: Dec 13, 2011
• Expiry date: Dec 3, 2029

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2601/14
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention relates to di(hetero)arylcyclohexane derivatives of the formula I,in which Ar1, Ar2, R1 and R2 have the meanings indicated in the claims. The compounds of the formula I are valuable pharmaceutical active compounds which inhibit ATP-sensitive potassium channels in the heart muscle and are suitable, for example, for the treatment of disorders of the cardiovascular system such as arrhythmias or a decreased contractility of the heart, such as can occur, for example, in coronary heart disease, cardiac insufficiency or cardiomyopathies. In particular, they are suitable for the prevention of sudden cardiac death. The invention furthermore relates to processes and intermediates for the preparation of the compounds of the formula I, their use and pharmaceutical compositions comprising them.