2-cyanophenyl-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine compounds, compositions and uses thereof

US8076345B2 · kind B2 · utility

Assignee

• EVOTEC AG · DE

Inventors

• Zhi-Liang Wei · South San Francisco, US
• Donogh John Roger O'Mahony · San Mateo, US
• Matthew Duncton · San Francisco, US
• John Kincaid · Hayward, US
• Michael G. Kelly · Thousand Oaks, US
• Zhan Wang · San Jose, US

Key dates

• Filing date: Mar 31, 2008
• Grant date: Dec 13, 2011
• Expiry date: Mar 26, 2030

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D519/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Fused heterocyclic compounds are provided according to formula 1:where R1, R2, R3, and m are as defined herein. Provided compounds and pharmaceutical compositions thereof are useful for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, cognitive disorders, anxiety, depression, and others.