Multispecfic deimmunized CD3-binders

US8076459B2 · kind B2 · utility

Assignee

• Micromet AG · DE

Inventors

• Robert Hofmeister · Scituate, US
• Birgit Kohleisen · Munich, DE
• Ulla Lenkkeri-Schütz · Unterschleißheim, DE
• Christian Itin · Menlo Park, US
• Patrick Bauerle · Gauting, DE
• Francis Joseph Carr · Aberdeen, GB
• Anita Hamilton · Aberdeen, GB
• Stephen Williams · Laramie, US

Key dates

• Filing date: Oct 15, 2004
• Grant date: Dec 13, 2011
• Expiry date: May 26, 2028

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2317/567
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention provides a cytotoxically active CD3 specific binding construct comprising a first domain specifically binding to human CD3 and an IG-derived second binding domain. Furthermore, a nucleic acid sequence encoding a CD3 specific binding construct is provided. Further aspects of the invention are vectors and host cells comprising the nucleic acid sequences, a process for the production of the construct and composition comprising the construct. The invention also provides the use of the constructs for the preparation of pharmaceutical compositions for the treatment of particular diseases, a method for the treatment of particular diseases and a kit comprising the binding construct of the invention.