Preparative-scale separation of enantiomers of chiral carboxylic acids
US8076511B2 · kind B2 · utility
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Key dates
| Filing date | May 18, 2007 |
| Grant date | Dec 13, 2011 |
| Priority date | — |
| Expiry date | Sep 1, 2029 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07B2200/07
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
High yields and purity are obtained in the purification of enantiomers of chiral carboxylic acids by preparative-scale chromatography by including a tertiary alcohol in the mobile phase in conjunction with an acidic modifier and a hydrophobic solvent. The tertiary alcohol is superior to other, more commonly used alcohols by reducing the extent of esterification of the enantiomer that otherwise lowers the yield and the purity.
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