Chiral diacylhydrazine ligands for modulating the expression of exogenous genes via an ecdysone receptor complex
US8076517B2 · kind B2 · utility
17Cited by
5References
5Claims
0Family size
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Key dates
| Filing date | May 29, 2008 |
| Grant date | Dec 13, 2011 |
| Priority date | — |
| Expiry date | Nov 26, 2029 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C2601/14
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides diacylhydrazine ligands and chiral diacylhydrazine ligands for use with ecdysone receptor-based inducible gene expression systems. Thus, the present invention is useful for applications such as gene therapy, large scale production of proteins and antibodies, cell-based screening assays, functional genomics, proteomics, metabolomics, and regulation of traits in transgenic organisms, where control of gene expression levels is desirable. An advantage of the present invention is that it provides a means to regulate gene expression and to tailor expression levels to suit the user's requirements.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.