Determination of a measure of a glycation end-product or disease state using tissue fluorescence
US8078243B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Nov 17, 2006 |
| Grant date | Dec 13, 2011 |
| Priority date | — |
| Expiry date | Sep 14, 2030 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61B5/441
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
A method of determining a measure of a tissue state (e.g., glycation end-product or disease state) in an individual. A portion of the tissue of the individual is illuminated with excitation light, then light emitted by the tissue due to fluorescence of a chemical with the tissue responsive to the excitation light is detected. The detected light can be combined with a model relating fluorescence with a measure of tissue state to determine a tissue state. The invention can comprise single wavelength excitation light, scanning of excitation light (illuminating the tissue at a plurality of wavelengths), detection at a single wavelength, scanning of detection wavelengths (detecting emitted light at a plurality of wavelengths), and combinations thereof. The invention also can comprise correction techniques that reduce determination errors due to detection of light other than that from fluorescence of a chemical in the tissue. For example, the reflectance of the tissue can lead to errors if appropriate correction is not employed. The invention can also comprise a variety of models relating fluorescence to a measure of tissue state, including a variety of methods for generating such models…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.