Method and arrangement for the online regulation of a batch process in a bioreactor

US8078322B2 · kind B2 · utility

Assignee

• Siemens Aktiengesellschaft · DE

Inventors

• Herbert Grieb · Malsch, DE
• Karl-Heinz Kirchberg · Karlsruhe, DE
• Edmund Linzenkirchner · Blankenloch, DE
• Ingrid Maes · Zwijndrecht, BE
• Bernd-Markus Pfeiffer · Nieheim, DE

Key dates

• Filing date: Aug 23, 2005
• Grant date: Dec 13, 2011
• Expiry date: Jul 21, 2028

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C02F3/006
• WIPO field: Control
• WIPO sector: Instruments

Abstract

The invention relates to the online regulation of a batch process in a bioreactor. According to the invention, spectra of the actual charge in the bioreactor are recorded at successive points during the running batch process. A measuring vector is produced, for each spectrum, in the low-dimensional main constituent region by the main constituent analysis of the high-dimensional spectra. The deviation is calculated between the measuring vector and a corresponding vector of a nominal trajectory consisting of measuring vectors of a reference charge, which are determined in an earlier batch process, and at least one adjustment operation for the batch process is determined and carried out according to said deviation. The direction of the adjustment operation is maintained when the deviation determined from one point to the next decreases, and modified when the deviation determined from one point to the next remains the same or increases.