Dispersion for pulmonary delivery of a bioactive agent

US8080263B2 · kind B2 · utility

Assignee

• Novartis AG · CH

Inventors

• Luis A. Dellamary · San Marcos, US
• Thomas E. Tarara · San Diego, US
• Alexey S. Kabalnov · Corvallis, US
• Jeffry Weers · San Diego, US
• Ernest G. Schutt · San Diego, US

Key dates

• Filing date: May 27, 2008
• Grant date: Dec 20, 2011
• Expiry date: Jan 18, 2029

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S977/926
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Stabilized dispersions are provided for the delivery of a bioactive agent. The dispersions preferably comprise a plurality of perforated microstructures dispersed in a suspension medium that typically comprises a liquid fluorochemical. As density variations between the suspended particles and suspension medium are minimized and attractive forces between microstructures are attenuated, the disclosed dispersions are particularly resistant to degradation, such as by settling or flocculation. In particularly preferred embodiments the stabilized dispersions may be directly administered to the lung of a patient using an endotracheal tube or bronchoscope.