Shallow multi-well plastic chip for thermal multiplexing
US8080411B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Oct 20, 2008 |
| Grant date | Dec 20, 2011 |
| Priority date | — |
| Expiry date | Jan 12, 2030 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10T436/25
- WIPO fieldOther special machines
- WIPO sectorMechanical engineering
Abstract
Disposable units in current use for performing PCR are limited by their heat block ramping rates and by the thermal diffusion delay time through the plastic wall as well as by the sample itself. This limitation has been overcome by forming a disposable plastic chip using a simple deformation process wherein one or more plastic sheets are caused, through hydrostatic pressure, to conform to the surface of a suitable mold. After a given disposable chip has been filled with liquid samples, it is brought into close contact with an array of heating blocks that seals each sample within its own chamber, allowing each sample to then be heat treated as desired.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.