Tricyclic angiotensin II agonists

US8080571B2 · kind B2 · utility

Assignee

• VICORE PHARMA AB · SE

Inventors

• Mathias Alterman · Stockholm, SE
• Anders Hallberg · Stockholm, SE
• Xiongyu Wu · Uppsala, SE

Key dates

• Filing date: Apr 12, 2006
• Grant date: Dec 20, 2011
• Expiry date: Feb 25, 2029

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P37/02
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

There is provided compounds of formula I,wherein A, X1, X2, X3, X4, Y1, Y2, Y3, Y4, Z1, Z2, R4 and R5 have meanings given in the description, and pharmaceutically-acceptable salts thereof, which compounds are useful as selective agonists of the AT2 receptor, and thus, in particular, in the treatment of inter alia gastrointestinal conditions, such as dyspepsia, IBS and MOF, and cardiovascular disorders.