Gamma-lactam compounds for promoting bone growth
US8080575B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | May 26, 2009 |
| Grant date | Dec 20, 2011 |
| Priority date | — |
| Expiry date | Jun 25, 2030 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61L2430/26
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides compounds, compositions and methods for promoting bone growth. Compounds useful in the methods of the present invention include compounds of Formula I, wherein each R1 and R2 is H, halogen, C1-6 alkyl, C1-6 alkoxy, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkoxy, —OR4, —NR4R5, —SR4, —C(O)R4, —C(O)OR4, —C(O)NR4R5, —N(R4)C(O)R5, —N(R4)C(O)OR5, —N(R4)C(O)NR4R5, —OP(O)(OR4)2, —S(O)2OR4, —S(O)2NR4R5, —CN, cycloalkyl, heterocycloalkyl, aryl or heteroaryl. Each R4 and R5 is H or C1-6 alkyl. X is O, S or NR4. Y is an aryl ring system having 6-10 ring members or a heteroaryl ring system having 5-10 ring members where 1-3 ring members are each N, O or S. Subscript n is 1 or 2. The compounds also include salts, hydrates and isomers of the compounds of the present invention.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.