Methods of making efavirenz and intermediates thereof
US8080655B2 · kind B2 · utility
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17Claims
0Family size
Assignee
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Key dates
| Filing date | Jul 20, 2009 |
| Grant date | Dec 20, 2011 |
| Priority date | — |
| Expiry date | Dec 16, 2029 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C2601/02
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention provides a process for the preparation of Efavirenz. A compound of Formula 1:may be prepared by a process comprising cyclizing, in the presence of a first base, a compound of Formula 5 with a haloformate of Formula 6. Other processes are also provided as well as novel compounds prepared by and used in such processes.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.