Compounds of reverse turn mimetics and the use thereof
US8080657B2 · kind B2 · utility
10Cited by
28References
4Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Oct 15, 2008 |
| Grant date | Dec 20, 2011 |
| Priority date | — |
| Expiry date | Oct 15, 2028 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P35/02
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Conformationally constrained compounds that are novel and mimic the secondary structure of reverse-turn regions of biologically active peptides and proteins and having bicyclic framework are disclosed, as well as their prodrugs. Such reverse-turn mimetic structures and prodrugs have utility over a wide range of fields, including use as diagnostic and therapeutic agents. The invention also relates to a use of such compounds for the preparation of a medicament for treating or preventing cancer including an acute myeloid leukemia.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.