High throughput magnetic isolation technique and device for biological materials

US8083069B2 · kind B2 · utility

Assignee

• General Electric Company · US

Inventors

• Sunil Srinivasa Murthy · Chennai, IN
• Aaron Joseph Dulgar-Tulloch · Clifton Park, US
• James William Bray · Niskayuna, US
• Shankar Chandrasekaran · Viralimalai, IN
• Arvind Kumar Tiwari · Bengaluru, IN

Key dates

• Filing date: Jul 31, 2009
• Grant date: Dec 27, 2011
• Expiry date: Oct 29, 2029

Classification

• Technology area (CPC B): Performing Operations; Transporting
• CPC primary: B03C2201/26
• WIPO field: Chemical engineering
• WIPO sector: Chemistry

Abstract

The present application discloses a process for the high throughput separation of at least one distinct biological material from a sample using magnetic tags and a magnetic separation set up capable of processing at least about 106 units/second. A magnetic field gradient is used to deflect target material bearing a magnet tag from one laminar flow stream to another so that the magnetically tagged target material exits a separation chamber via a different outlet than the rest of the sample. The process is applicable to isolating several distinct biological materials by directing each via magnetic deflection to its own unique outlet. The application also discloses a system for performing the process and a kit that includes the system and the magnetic tags.