Use of mycrobacterial vaccines in CD4+ or CD8+ lymphocyte-deficient mammals
US8084041B2 · kind B2 · utility
1Cited by
18References
9Claims
0Family size
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Key dates
| Filing date | Jan 23, 2004 |
| Grant date | Dec 27, 2011 |
| Priority date | — |
| Expiry date | Apr 17, 2024 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K2039/522
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Methods of treating a mammal that is deficient in CD4+ and/or CD8+ lymphocytes are provided. The methods comprise inoculating the mammal with an attenuated mycobacterium in the M. tuberculosis complex. In these methods, the mycobacterium comprises two deletions, wherein a virulent mycobacterium in the M. tuberculosis complex having either deletion exhibits attenuated virulence. Use of these mycobacteria for the manufacture of a medicament for the treatment of mammals deficient in CD4+ and/or CD8+ lymphocytes is also provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.