Thiazole compounds and methods of use

US8084479B2 · kind B2 · utility

Assignee

• AMGEN INC. · US

Inventors

• Qingping Zeng · Thousand Oaks, US
• John Gordon Allen · Newbury Park, US
• Matthew P. Bourbeau · Calabasas, US
• Celia Dominguez · Los Angeles, US
• Christopher H. Fotsch · Thousand Oaks, US
• Nianhe Han · Newbury Park, US
• Fang-Tsao Hong · Thousand Oaks, US
• Xin Huang · Brookline, US
• Matthew Lee · Calabasas, US
• Aiwen Li · Westlake Village, US
• Qingyian Liu · Camarillo, US
• James T. Rider · Calabasas, US
• Seifu Tadesse · Simi Valley, US
• Andrew Tasker · Simi Valley, US
• Vellarkad N. Viswanadhan · Nagamangala, IN
• Xianghong Wang · Dublin, US
• Kurt E. Weiler · Thousand Oaks, US
• George E. Wohlhieter · San Fernando, US
• Guomin Yao · Mililani, US
• Chester Chenguang Yuan · Newbury Park, US

Key dates

• Filing date: Feb 11, 2009
• Grant date: Dec 27, 2011
• Expiry date: Jun 7, 2030

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D513/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The invention relates to methods of using thiazole compounds of Formula I and Formula II and compositions thereof for treating diseases mediated by protein kinase B (PKB) such as cancer and other proliferative disorders where the variables have the definitions provided herein.